Desiderio da Settignano, born in a small village in the hills above Florence, numbers among the most brilliant marble sculptors of the Renaissance. His mastery of relief sculpture is apparent in this pictorially rich image, with its complicated space in which figures move in different planes, all suggested by the subtlest manipulations of the marble surface.
Clearly Desiderio had learned much from the low-relief techniques of Donatello. The sculptor invented a rocky, wilderness landscape with a cloud-streaked sky and tall, pointed cypress trees receding into the distance among the cliffs. In the foreground, Saint Jerome kneels in penitential prayer before a crucifix. He wears only a few crumpled wisps of drapery, and his gaunt face tells of fervent, ascetic devotion. On the right, in particularly fine low relief, suggesting he is some distance in the background, a terrified boy flees from the lions that emerge from the rocks on the left behind the cross.
According to legend, Jerome tamed a lion by removing a thorn from its paw, and the lion therefore often appears as his attribute in art. The lions here, clearly no threat to the saint, suggest his harmonious relationship with nature, achieved through solitary meditation, prayer, and penance.