In this vivid image, Anthony van Dyck portrays the Virgin Mary gracefully ascending heavenward. With open arms and hands, she looks upward expectantly. Various putti surrounding her hold objects signifying Christ's Passion, among them the cross, the crown of thorns, and the veil. Another putto crowns her with a wreath of roses, signifying her role as intercessor for man's redemption. The word "rosary," the prayer beads used to aid in Catholic devotion, means "wreath of roses."
Stylistically, this tender devotional painting is characteristic of the religious images Van Dyck painted around 1628–1629 just after he returned to Antwerp from an extended stay in Italy. His expressive brushstrokes reflect his careful studies in Venice and Rome of Titian, while his depiction of the Virgin with her upward gaze is reflects his familiarity with the work of Guido Reni, whose works he also saw in Rome. The subject also harkens to a painting Van Dyck had executed in 1624–1625 in Palermo. In that altarpiece, Van Dyck depicted the plague saint Rosalie being borne up to heaven to intercede on behalf of plague victims. The Virgin is the patron saint of Antwerp and Van Dyck has here revised his earlier composition of Rosalie ascending in this tender image of the Virgin as intercessor for mankind.