After four years in Florence, Raphael moved to Rome in 1508, probably to execute more significant commissions under the papal reign of Julius II. The major work in America from Raphael's Roman period is The Alba Madonna. In this "Madonna of Humility" the Virgin is seated directly on the ground instead of on a heavenly throne or a sumptuous cushion. The artist grouped the figures in a broad low pyramid, aligning them within a circle in such a way that they not only conform to their space, but dominate it as well. The tondo, or round–format style, was popular in Florentine painting, and the influence of the Florentine masters Michelangelo and Leonardo is also apparent in the work.
The Alba Madonna shows the Roman style Raphael adapted, in the painting’s delicacy of color and mood, with figures draped in rose pink, pale blue, and green, set in an idealized, classical landscape. The Madonna is dressed in an antique costume of turban, sandals, and flowing robes. The serene, bucolic atmosphere of Raphael's tondo belies its emotional meaning. The Christ Child's gesture of accepting the cross from the Baptist is the focus of attention of all three figures, as if they have foreknowledge of Christ's sacrifice for mankind.